Development is being led by Rockstar Vancouver in collaboration with the company's New England, London and Toronto studios.
Lead writer of "Max Payne 3" is Dan Houser, noted as the writer of Rockstar's "Grand Theft Auto" series and the award-winning "Red Dead Redemption".
"This is Max as we've never seen him before," said Rockstar's Sam Houser. "A few years older, more world-weary and cynical than ever."
The game will be set in São Paulo, Brazil, where 'Max Payne' is working in the private security sector for a wealthy local family.